2016年3月22日 星期二

期刊文章:Meta-Analysis: Association between Hypoglycaemia and Serious Adverse Events in Older Patients

資料來源:http://www.jdcjournal.com/article/S1056-8727%2816%2930055-1/abstract

Meta-Analysis: Association between Hypoglycaemia and Serious Adverse Events in Older Patients
Katharina Mattishent,
Yoon Kong Loke
Norwich Medical School, University of East Anglia, Norwich NR4 7TJ
DOI: http://dx.doi.org/10.1016/j.jdiacomp.2016.03.018

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Abstract
Aims

We aimed to conduct a meta-analysis of serious adverse events (macro- and micro-vascular events, falls and fractures, death) associated with hypoglycaemia in older patients.
Methods

We searched MEDLINE and EMBASE spanning a ten-year period up to March 2015 (with automated PubMed updates to October 2015). We selected observational studies reporting on hypoglycaemia and associated serious adverse events, and conducted a meta-analysis. We assessed study validity based on ascertainment of hypoglycaemia, adverse events and adjustment for confounders.
Results

We included 17 studies involving 1.5 million participants. Meta-analysis of eight studies demonstrated that hypoglycemic episodes were associated with macrovascular complications, odds ratio (OR) 1.83 (95% Confidence Interval [CI] 1.64, 2.05), and microvascular complications in two studies OR 1.77 (95% CI 1.49, 2.10). Meta-analysis of four studies demonstrated an association between hypoglycaemia and falls or fractures, OR 1.89 (95% CI 1.54, 2.32) and 1.92 (95% CI 1.56, 2.38) respectively. Hypoglycaemia was associated with increased likelihood of death in a meta-analysis of eight studies, OR 2.04 (95% Confidence Interval 1.68, 2.47).
Conclusion

Our meta-analysis raises major concerns about a range of serious adverse events associated with hypoglycaemia. Clinicians should prioritize individualized therapy and closer monitoring strategies to avoid hypoglycaemia in susceptible older patients.

Keywords: Hypoglycaemia, Diabetes Mellitus, Falls, Fractures, Cardiovascular Disease

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