Aging Dis. 2015 Feb; 6(1): 56–75.Published online 2014 Feb 16. doi: 10.14336/AD.2014.0209
The Intricate Interplay between Mechanisms Underlying Aging and Cancer
Amanda Piano and Vladimir I. Titorenko*
Age is the major risk factor in the incidence of cancer, a hyperplastic disease associated with aging. Here, we discuss the complex interplay between mechanisms underlying aging and cancer as a reciprocal relationship. This relationship progresses with organismal age, follows the history of cell proliferation and senescence, is driven by common or antagonistic causes underlying aging and cancer in an age-dependent fashion, and is maintained via age-related convergent and divergent mechanisms. We summarize our knowledge of these mechanisms, outline the most important unanswered questions and suggest directions for future research.
Keywords: aging, cancer, cell cycle, cellular senescence, cell death, cellular signaling