期刊文章:Redox parameters as markers of the rate of aging and predictors of lifespan

From:https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glz033/5315542

Redox parameters as markers of the rate of aging and predictors of lifespan
Irene Martínez de Toda, MSc Carmen Vida, PhDAntonio Garrido, PhD Mónica De la Fuente, PhD, MD
The Journals of Gerontology: Series A, glz033,https://doi.org/10.1093/gerona/glz033
Published:
11 February 2019

Abstract

Oxidative stress has been reported to increase with aging and although several age-related changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (catalase, glutathione peroxidase and reductase activities and reduced glutathione) and oxidant (oxidized glutathione, basal superoxide anion and malondialdehyde concentrations) parameters were studied in whole blood cells from humans divided into different age groups (adult, mature, elderly, nonagenarian and centenarian) in a cross-sectional study. Moreover, the same parameters were investigated in peritoneal leukocytes of mice at the analogous human ages (adult, mature, old, very old and long-lived) in a longitudinal study as well as in adult prematurely aging mice (PAM). The results reveal that the age-related alterations of these markers are similar in humans and mice, with decreased antioxidants and increased oxidants in old subjects whereas long-lived individuals show similar values to those in adults. Additionally, adult PAM showed similar values to those in chronologically old mice and had a shorter lifespan than non-prematurely aging mice. Thus, these parameters could be proposed as markers of the rate of aging and used to ascertain biological age in humans.
Keywords: antioxidants, oxidants, longevity, biological age markers, oxidative stress
Topic:
aging
antioxidants
oxidative stress
glutathione
adult
catalase
glutathione disulfide
glutathione peroxidase
leukocytes
longevity
malondialdehyde
oxidants
oxidation-reduction
oxidoreductase
superoxides
mice
peritoneum
whole blood
elderly
nonagenarians
life span
verification
Issue Section: Original Article